Idiopathic membranoproliferative glomerulonephritis: does it exist?
نویسندگان
چکیده
منابع مشابه
Full Review Idiopathic membranoproliferative glomerulonephritis: does it exist?
When membranoproliferative glomerulonephritis (MPGN) was first delineated as a discrete clinico-pathological entity more than a half-century ago, most cases were regarded as idiopathic (or primary) in nature. Advances in analysis of pathogenetic mechanisms and etiologies underlying the lesion of MPGN have radically altered the prevalence of the truly idiopathic form of MPGN. In addition, MPGN a...
متن کاملChapter 8: Idiopathic membranoproliferative glomerulonephritis
BACKGROUND MPGN is a light-microscopic ‘‘pattern of injury’’ caused by many disorders (see Table 20). Patients commonly present with nephrotic syndrome, hypertension, glomerular hematuria, and progressive kidney dysfunction. Reduction in the serum concentration of complement components (C3 and/or C4) is commonly, but not uniformly, observed. MPGN can be further classified based on the extent an...
متن کاملMembranoproliferative Glomerulonephritis
Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
متن کاملTreatment of idiopathic membranoproliferative glomerulonephritis with mycophenolate mofetil and steroids.
BACKGROUND Treatment of adults with idiopathic membranoproliferative glomerulonephritis (IMPGN) is often unrewarding with approximately 60% of patients progressing to end-stage renal failure within 10 years. Although children with IMPGN may respond to steroid therapy, there is no significant benefit to treating adult IMPGN patients with immunosuppression. METHODS Outcome measures in five pati...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2013
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gft058